VHL polyclonal antibody (A01)
产品名称： VHL polyclonal antibody (A01)
英文名称： VHL polyclonal antibody (A01)
产品编号： H00007428-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant VHL.
- Immunogen:
- VHL (NP_000542, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.
- Sequence:
- MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
- MSDS:
Download
- Application Image
- Western Blot (Recombinant protein)
- ELISA
- Entrez GeneID:
- 7428
- GeneBank Accession#:
- NM_000551
- Protein Accession#:
- NP_000542
- Gene Name:
- VHL
- Gene Alias:
- HRCA1,RCA1,VHL1
- Gene Description:
- von Hippel-Lindau tumor suppressor
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
- Other Designations:
- elongin binding protein
- Related Disease
- Adenocarcinoma
- Adrenal Gland Neoplasms
- Altitude Sickness
- Anoxia
- Breast cancer
- Breast Neoplasms
- Carcinoma, Renal Cell
- Cardiovascular Diseases
- Central Nervous System Neoplasms
- Cerebellar Neoplasms
- Diabetes Mellitus, Type 2
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Glomus Tumor
- Head and Neck Neoplasms
- Hemangioblastoma
- Hemangioma, Capillary
- Hippel-Lindau Disease