TMED10 polyclonal antibody
产品名称： TMED10 polyclonal antibody
英文名称： TMED10 polyclonal antibody
产品编号： PAB13235
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TMED10.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 19 amino acids of human TMED10.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.Nature. 2006 Apr 27;440(7088):1208-12.
- 2.
- Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.J Neurosci Res. 2004 Aug 1;77(3):309-22.
- 3.
- Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.
Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I.J Biol Chem. 1996 Jul 19;271(29):17183-9.
- Entrez GeneID:
- 10972
- Protein Accession#:
- AAD31941
- Gene Name:
- TMED10
- Gene Alias:
- P24(DELTA),S31I125,S31III125,TMP21,Tmp-21-I
- Gene Description:
- transmembrane emp24-like trafficking protein 10 (yeast)
- Omim ID:
- 605406
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq
- Other Designations:
- 21 kDa transmembrane trafficking protein,transmembrane emp24 domain-containing protein 10
- Related Disease